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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/25906

Title: The Role of ps20 in Two Respiratory Virus Infections: MHV-1 and Influenza A/WSN/33 H1N1
Authors: Rogers, Erin
Advisor: Fish, Eleanor N.
Department: Immunology
Keywords: whey acidic protein
ps20
influenza
MHV-1
neutrophil
Issue Date: 13-Jan-2011
Abstract: The objective of this thesis was to examine the role of ps20 in virus infections. We provide evidence that MHV-1 infection resulted in increased lung viral titers in ps20-/- mice. These data highlight an antiviral role for ps20 in MHV-1 infection. We also observed an increase in the percentage of GR1+ neutrophils infiltrating the BAL and in the lung draining lymph node of ps20-/- mice, on day 2 post-infection. In vitro, gene expression analysis identified an increase in expression of CXCL1 and CXCL2 in MHV-1 infected ps20-/- fibroblasts. These data suggest a role for ps20 in regulating neutrophil chemotactic factors, and migration. Next, we examined influenza A/WSN/33, and provide evidence that ps20 functions as a proviral factor. In vivo, ps20-/- mice infected with influenza A/WSN/33 exhibited decreased lung viral titers. These data suggest that ps20 functions as either a proviral or antiviral agent, dependent on the infecting virus.
URI: http://hdl.handle.net/1807/25906
Appears in Collections:Master

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