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Till, James E. >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/26399

Title: Granulopoietic Progenitors in Suspension Culture - Comparison of Stimulatory Cells and Conditioned Media
Authors: Niho, Y.
Till, J. E.
McCulloch, E. A.
Issue Date: Jun-1975
Publisher: American Society of Hematology
Citation: NIHO, Y., TILL, J. E., & MCCULLOCH, E. A. (1975). Granulopoietic progenitors in suspension culture - comparison of stimulatory cells and conditioned media. Blood, 45(6), 811-821.
Series/Report no.: Blood
Vol. 45 No. 6
Abstract: Kinetic studies have been carried out to investigate the functional heterogeneity previously observed in populations of human marrow or peripheral blood cells separated by velocity sedimentation. The results obtained confirm the earlier results, in that slowly-sedimenting cells were found to stimulate both colony formation by granulopoietic progenitors and an increase in numbers of granulopoietic progenitors in suspension culture, while rapidly-sedimenting cells stimulated only colony formation and not increased progenitors in suspension cultures. Investigations of the properties of media conditioned by these two subpopulations of cells revealed no clear differences between them; both stimulated suspension cultures as well as colony formation, and both lost the former activity, but not the latter, after dialysis. The results contribute to the evidence that more than one process is regulated in cultures of granulopoietic progenitor cells.
Description: This research was originally published in Blood. NIHO, Y., TILL, J. E., & MCCULLOCH, E. A. (1975). Granulopoietic progenitors in suspension culture - comparison of stimulatory cells and conditioned media. Blood, 45(6), 811-821. © the American Society of Hematology.
URI: http://hdl.handle.net/1807/26399
ISSN: 0006-4971
http://bloodjournal.hematologylibrary.org/
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/45/6/811
Appears in Collections:Till, James E.

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