test Browse by Author Names Browse by Titles of Works Browse by Subjects of Works Browse by Issue Dates of Works

Advanced Search
& Collections
Issue Date   
Sign on to:   
Receive email
My Account
authorized users
Edit Profile   
About T-Space   

T-Space at The University of Toronto Libraries >
University Professors >
Till, James E. >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/26401

Title: Specificity of Interacting Populations Affecting Granulopoiesis in Culture
Authors: Messner, H. A.
Till, J. E.
McCulloch, E. A.
Issue Date: Nov-1974
Publisher: American Society of Hematology
Citation: MESSNER, H. A., TILL, J. E., & MCCULLOC.EA. (1974). Specificity of interacting populations affecting granulopoiesis in culture. Blood, 44(5), 671-682.
Series/Report no.: Blood
Vol. 44 No. 5
Abstract: Human marrow contains two interacting populations that affect granulopoiesis in culture. The first population consists of committed granulopoietic progenitors, while the second contains cells that produce factors whose activity is essential for granulopoiesis in culture. The two populations can be separated by an adherence procedure and assayed independently. Both populations proved to be heterogeneous: the granulopoietic progenitor pool contains a subpopulation which fails to respond to semipurified colony-stimulating activity derived from peripheral leukocytes but responds to the unpurified material. The population of "factor-producing" cells contains two subpopulations that can be separated on the basis of size by velocity sedimentation. Both produce factors that stimulate granulopoietic colony formation. However, the more slowly sedimenting subpopulation is capable of interacting with granulopoietic progenitors in suspension culture yielding an increase in their number, while cells from the more rapidly sedimenting population failed to support such an increase. The results are interpreted as indicating specificity in the interaction between granulopoietic progenitors and factor-producing cells.
Description: This research was originally published in Blood. MESSNER, H. A., TILL, J. E., & MCCULLOC.EA. (1974). Specificity of interacting populations affecting granulopoiesis in culture. Blood, 44(5), 671-682. © the American Society of Hematology.
URI: http://bloodjournal.hematologylibrary.org/
ISSN: 0006-4971
Appears in Collections:Till, James E.

Files in This Item:

File Description SizeFormat
specificity of interacting populations affecting granulopolesis in culture.pdf1.66 MBAdobe PDF

Items in T-Space are protected by copyright, with all rights reserved, unless otherwise indicated.