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Till, James E. >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/26402

Title: Interacting Cell Populations Affecting Granulopoietic Colony Formation by Normal and Leukemic Human Marrow Cells
Authors: Messner, H. A.
Till, J. E.
McCulloch, E. A.
Issue Date: 1973
Publisher: American Society of Hematology
Citation: MESSNER, H. A., TILL, J. E., & MCCULLOC.EA. (1973). Interacting cell populations affecting granulopoietic colony formation by normal and leukemic human marrow cells. Blood, 42(5), 701-710.
Series/Report no.: Blood
Vol. 42 No. 5
Abstract: Marrow from 28 nonleukemic individuals was separated by adherence to glass or plastic into nonadherent (NA) and adherent populations. The NA populations were found to be more dependent for colony formation in culture on added colonystimulating activity (CSA) than unseparated marrow suspensions, and therefore proved useful for CSA assays. Quantitative reconstitution procedures were used to assay CSA-producing cells. Either increasing numbers of irradiated unseparated marrow, or adherent cells derived from varying numbers of marrow cells, were used to restore colony-forming efficiency to NA populations. Assay procedures for CSA-producing cells were applied to four patients with acute leukemia prior to treatment. In all four instances, a defect in CSA-producing cells was demonstrated.
Description: This research was originally published in Blood. MESSNER, H. A., TILL, J. E., & MCCULLOC.EA. (1973). Interacting cell populations affecting granulopoietic colony formation by normal and leukemic human marrow cells. Blood, 42(5), 701-710. © the American Society of Hematology.
URI: http://bloodjournal.hematologylibrary.org/
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/42/5/701
http://hdl.handle.net/1807/26402
ISSN: 0006-4971
Appears in Collections:Till, James E.

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