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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/27331

Title: Can Molecules Released From Skeletal Muscle Infuence The Heart? The Effect Of Fibre Type and HSP Content.
Authors: Di Battista, Alex
Advisor: Locke, Marius
Department: Exercise Sciences
Keywords: Exercise Science
Cardiovascular
Issue Date: 30-May-2011
Abstract: Skeletal muscle damage can lead to cell death and the subsequent release of intracellular molecules. To investigate whether molecules from skeletal muscle can interact with the heart, the Langendorff isolated heart preparation was used to assess cardiac function, while NF-κB and AP-1 activation were assessed by EMSA to observe inflammatory status. Hearts were perfused for 75 min with 1 μg/ml of either soleus, white gastrocnemius (WG), or heat stressed white gastrocnemius (HSWG) skeletal muscle homogenate and a decreased LVDP, +dP/dt and –dP/dt were observed when compared to untreated (control) hearts. Greater early and late decreases in cardiac function were observed in hearts treated with HSWG and soleus muscle homogenates, respectively. No alterations in NF-κB or AP-1 activation were detected. These data suggests the contents of skeletal muscle are capable of interacting with the heart and altering contractile function in a fibre type specific manner, possibly related to muscle HSP content.
URI: http://hdl.handle.net/1807/27331
Appears in Collections:Master

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