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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/27349

Title: Diffusion Tensor Imaging Investigations of Mild Brain Damage
Authors: Koshimori, Yuko
Advisor: Green, Robin
Department: Rehabilitation Science
Keywords: mild traumatic brain injury
spinal cord injury
diffusion tensor imaging
white matter damage
Issue Date: 31-May-2011
Abstract: In two separate studies, we used diffusion tensor imaging (DTI)to examine white matter changes secondary to traumatic brain injury (TBI) and spinal cord injury (SCI). The first study examined the utility of DTI for a single case diagnosis of mild TBI (mTBI) and demonstrated that the anterior limb of the internal capsule and the genu of the corpus callosum were sensitive and specific to mTBI. The second study examined the sub-acute effects of SCI on white matter tissue in the brain and demonstrated that SCI patients have a significantly greater degree of FA asymmetry than control subjects in the superior and posterior corona radiata. The first study has provided preliminary proof of principal evidence that DTI can be used to diagnose mTBI in individual cases. The second study suggests that the degree of asymmetry may be a useful biomarker for detecting subtle white matter changes.
URI: http://hdl.handle.net/1807/27349
Appears in Collections:Master

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