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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/27547

Title: A Role for a Novel β-catenin Binding Protein in Epithelial-mesenchymal Transitions and Breast Cancer Progression
Authors: Sikorski, Lindsay
Advisor: Rozakis-Adcock, Maria
Department: Laboratory Medicine and Pathobiology
Keywords: EMT
basal phenotype breast cancer
Issue Date: 2-Jun-2011
Abstract: Epithelial-mesenchymal transition (EMT) has a critical role in tumor progression and has been correlated with the basal-like subtype of human breast cancers. Here I report a novel β-catenin binding protein, which I have shown to be expressed in invasive breast cancer and hypothesized to have a role in breast tumor progression. In normal breast tissue, expression is restricted to the myoepithelium while in breast cancer the expression pattern is similar to smooth muscle actin and vimentin. I have demonstrated that silencing of this protein in breast tumor cells reduces migration by over 50 percent. Furthermore, I have identified this β-catenin binding protein as a target of the Snail EMT network and have demonstrated this protein to be a marker of basal-like carcinomas. These results define a role for this novel protein in EMT, as a marker for the basal subtype, and a promising therapeutic target for metastasis inhibition.
URI: http://hdl.handle.net/1807/27547
Appears in Collections:Master

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