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Medical Biophysics (MBP) >
Stem Cells >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/2774

Title: Spleen-colony formation in anemic mice of genotype WWv
Authors: McCulloch, Ernest A., mcculloc_at_uhnres.utoronto.ca
Siminovitch, Louis, lsiminovitch_at_mtsinai.on.ca
Till, James E., till_at_uhnres.utoronto.ca
Keywords: assay for progenitor cells
CFU
colony-forming units
genetics
genotype
hematopoietic progenitor cells
hematopoietic stem cells
hematopoietic stem cell transplantation
inbred mouse strains
mouse marrow
mouse spleen
spleen colonies
Issue Date: 15-May-1964
Publisher: American Association for the Advancement of Science
Citation: Science 1964(15 May); 144(1620): 844-846.
Abstract: The hemopoietic cells from anemic mice of genotype WWv are less able by 200-fold to take part in colony formation in the spleen than cells from the normal littermates of genotype ww. The genetic defect shows itself in the colony-forming cells, since cells from normal littermate mice form colonies in the spleens of unirradiated mice of genotype WWv. Use of animals of genotype WWv as recipients improves the spleen-colony method by removing bias resulting from the death of irradiated recipients.
Description: A version of the published article is available for those with access to JSTOR, via: http://tinyurl.com/6ewt3
URI: http://hdl.handle.net/1807/2774
Appears in Collections:Stem Cells
Till, James E.

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