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Medical Biophysics (MBP) >
Stem Cells >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/2776

Title: Cytological evidence for a relationship between normal hematopoietic colony-forming cells and cells of the lymphoid system
Authors: Wu, Alan M.
Till, James E., till_at_uhnres.utoronto.ca
Siminovitch, Louis, lsiminovitch_at_mtsinai.on.ca
McCulloch, Ernest A., mcculloc_at_uhnres.utoronto.ca
Keywords: bone marrow cells
CFU
chromosome markers
colony-forming units
cytology
hematopoietic stem cell transplantation
hematopoietic stem cells
hematopoietic progenitor cells
inbred mouse strains
lymph nodes
lymphoid tissue
mouse marrow
spleen colonies
thymus
Issue Date: 1-Mar-1968
Publisher: The Rockefeller University Press
Citation: J Exp Med 1968(Mar); 127(3): 455-464
Description: The relationship between hematopoietic colony-forming stem cells and cells in the thymus and lymph nodes of unirradiated mice has been investigated using a chromosome-marker technique. It was found that a high proportion of cells in the thymus may belong to the same clone as normal hematopoietic colony-forming cells. It was also found that cells belonging to the same clone as colony-forming cells may reach the lymph nodes, and that nodes containing such cells can participate in an immunological response against sheep red cells. Either the precursors of cells in thymus and lymph node are identical with hematopoietic colony-forming cells, or they are both descendants of a common precursor which has not yet been identified. The results are compatible with the view that ceils of the hematopoietic system and the immune system may be derived from the same stem cell. Reproduced from The Journal of Experimental Medicine, 1968(Mar); 127(3): 455-464 by copyright permission of The Rockefeller University Press (www.rockefeller.edu/rupress/).
URI: http://hdl.handle.net/1807/2776
Appears in Collections:Stem Cells
Till, James E.

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