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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/2777

Title: A stochastic model of stem cell proliferation, based on the growth of spleen colony-forming cells
Authors: Till, James E., till_at_uhnres.utoronto.ca
McCulloch, Ernest A., mcculloc_at_uhnres.utoronto.ca
Siminovitch, Louis, lsiminovitch_at_mtsinai.on.ca
Keywords: bone marrow cells
colony-forming units
hematopoietic progenitor cells
hematopoietic stem cells
hematopoietic stem cell transplantation
mouse marrow
probabilistic model
spleen colonies
stochastic processes
Issue Date: Jan-1964
Publisher: National Academy of Sciences (USA), http://www.pnas.org/
Citation: Proceedings of the National Academy of Sciences (USA) 1964(Jan); 51(1): 29-36
Description: In a previous study [J Cell Physiol 1963(Dec); 62(3): 327-336] it was found that most macroscopic colonies formed from transplanted mouse marrow cells in the spleens of irradiated mice contained new colony-forming units (CFU). However, the distribution of such CFU among colonies was very heterogeneous, with many colonies containing few colony-forming cells, and a few containing very many. This result suggests that control of the self-renewal of CFU is lax. In the present paper, an analysis of this variation is presented which indicates that it might be generated by a well-known probabilistic ("stochastic") process, the "birth-and-death" process. For permission to reprint this article for other than personal noncommercial use, the individual authors of articles should be contacted. See: http://www.pnas.org/misc/nlmterms.shtml (and also, http://www.pubmedcentral.gov/about/copyright.html).
URI: http://hdl.handle.net/1807/2777
Appears in Collections:Stem Cells
Till, James E.

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