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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/2778

Title: The distribution of colony-forming cells among spleen colonies
Authors: Siminovitch, Louis, lsiminovitch_at_mtsinai.on.ca
McCulloch, Ernest A., mcculloc_at_uhnres.utoronto.ca
Till, James E., till_at_uhnres.utoronto.ca
Keywords: assay for progenitor cells
colony-forming units
hematopoietic progenitor cells
hematopoietic stem cells
hematopoietic stem cell transplantation
heterogeneity of CFU per colony
inbred mouse strains
lax control of self renewal
mouse fetal liver
mouse marrow
mouse spleen
properties of stem cells
spleen colonies
Issue Date: Dec-1963
Publisher: Wiley-Liss, Inc., A Wiley Company
Citation: Journal of Cellular and Comparative Physiology 1963(Dec); 62(3): 327-336.
Description: Progenitor cells that are recognized by their ability to form colonies of descendants in the spleens of irradiated mice have the capacity for self-renewal. The distribution of new colony-forming cells per colony is extremely heterogeneous, indicating lax control of self-renewal. The capacities of colony-forming cells for self-renewal, for extensive proliferation, and for giving rise to differentiated descendants, fulfill three requirements for studies of stem cells. Thus, colony-forming cells may be considered to be class (though not necessarily the only class) of such progenitor cells, and the spleen colony method is a quantitative method for their detection. Journal of Cellular and Comparative Physiology copyright 1963 Wiley-Liss, Inc., A Wiley Company (www.interscience.Wiley.com).
URI: http://hdl.handle.net/1807/2778
Appears in Collections:Stem Cells
Till, James E.

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