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Stem Cells >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/2779

Title: Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells
Authors: Becker, Andrew J.
McCulloch, Ernest A., mcculloc_at_uhnres.utoronto.ca
Till, James E., till_at_uhnres.utoronto.ca
Keywords: bone marrow cells
chromosome markers
colony-forming units
hematopoietic stem cell transplantation
hematopoietic stem cells
hematopoietic progenitor cells
inbred mouse strains
mouse marrow
spleen colonies
Issue Date: 2-Feb-1963
Publisher: Nature Publishing Group
Citation: Nature 1963(2 Feb); 197(4866): 452-454.
Description: Normal mouse blood-forming tissue contains a class of cells which, on being transplanted into heavily irradiated mice, can proliferate and form macroscopic colonies in the spleen. Often, within a given colony, the cells which are observed indicate that differentiation is occurring along three lines, into cells of the erythrocytic, granulocytic and megakaryocytic series, respectively. Unique radiation-induced marker chromosomes were used to obtain direct cytological evidence that the spleen colonies are clones. Thus, the advantages inherent in the clonal approach to studies of the genetic and physiological properties of cells are available for investigations on hæ­¡topoiesis. Reproduced from Nature 1963(2 Feb); 197(4866): 452-454. The Nature website is www.nature.com
URI: http://hdl.handle.net/1807/2779
Appears in Collections:Stem Cells
Till, James E.

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