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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/29570

Title: The Role of the Dopamine D, Receptors in Cue-induced Reinstatement of Nicotine-seeking Behaviour
Authors: Khaled, Maram Ahmed Taha Mohamed
Advisor: Le Foll, Bernard
Le, Anh Dzung
Department: Pharmacology
Keywords: dopamine D3 receptors
addiction
brain
drug discovery
motivation
Issue Date: 25-Aug-2011
Abstract: Dopamine D3 receptors (DRD3) are implicated in relapse to drugs. The current study investigated the role of DRD3 in cue-induced reinstatement of nicotine-seeking in rats. Rats were trained to lever-press for intravenous infusions of nicotine, associated with the illumination of a cue-light, under a fixed-ratio schedule of reinforcement. Following extinction of the behaviour, where lever pressing had no consequences, reinstatement testing was performed by reintroduction of the cues after systemic or local administration (into discrete brain areas) of the DRD3 selective antagonist SB277011-A. Systemic antagonism of DRD3 significantly attenuated cue-induced reinstatement of nicotine-seeking. The same effect was observed upon infusions of SB277011-A into the basolateral amygdala or the lateral habenula, but not the nucleus accumbens. The current findings implicate DRD3 in cue-induced reinstatement of nicotine, delineate some of the neural substrates underlying this role and support a potential for using selective DRD3 antagonists for the prevention of relapse to smoking.
URI: http://hdl.handle.net/1807/29570
Appears in Collections:Master

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