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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/30598

Title: Genetic and Phenomic Determinants of Basal Mechano-sensitivity and Spread of Neuropathic Pain Following Transection of the Infraorbital Nerve in Mice
Authors: Froimovitch, Daniel
Advisor: Seltzer, Ze'ev
Department: Physiology
Keywords: Neuropathic Pain
Pain Spread
Pain Genetics
Issue Date: 7-Dec-2011
Abstract: Craniofacial nerve injury occasionally causes spread of mechanical hypersensitivity in humans. We modeled this abnormality by transecting the infraorbital nerve (IONX) in male and female mice of the 23 AXB-BXA recombinant inbred lines and their progenitor strains, comparing their responsivity to 7 applications of a 0.2 gram Von Frey filament to the ears, paws and tail. When normalizing their mechano-responsivity on postoperative days 14 and 21 by the preoperative values, subtracting data of sham-operated from IONX mice, highly contrasting line/strain-specific differences were demonstrated. Similar line/strain-specific variability in the spread of mechano-allodynia to the paws post-IONX was demonstrated in our novel 3 minute place-avoidance paradigm, assessing parameters of mobility on a smooth surface versus a pro-allodynic granular surface. These genetically-controlled, widespread changes in mechano-sensitivity caused by IONX were minimally sexually dimorphic and mapped to intervals on chromosomes 5, 9, and 13. Further analysis is needed to identify the causative genes.
URI: http://hdl.handle.net/1807/30598
Appears in Collections:Master

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