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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/30601

Title: Metabolic and Endocrine Adaptations to Chronically Low Body Mass in Female Wistar Rats
Authors: Gairdner, Sarah
Advisor: Amara, Catherine
Department: Exercise Sciences
Keywords: Food Restriction
Anorexia Nervosa
Issue Date: 7-Dec-2011
Abstract: Animal models have yet to characterize alterations in body composition, wheel running activity, food intake, and neuroendocrine parameters, in chronic food restriction. This study investigated changes in these measures in food restricted rats, with and without access to running wheels, over four weeks. The data demonstrated that upon initiation of food restriction IGF-1 reductions paralleled loss of lean tissue while leptin levels were rapidly reduced which paralleled losses in body fat. Further, a lower limit threshold of body fat was identified, below which the correlation between leptin and fat mass was disrupted. Lastly, a decrease and plateau in body mass was mirrored by an increase and plateau in voluntary wheel activity in the food restricted population. The data suggest that there is a tight biological link between hyperactivity and body mass and that adequate nutritional support might attenuate the drive for obligate exercise even before weight is fully restored.
URI: http://hdl.handle.net/1807/30601
Appears in Collections:Master

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