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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/31270

Title: Comparative Effects of a D2 and Mixed D1-D2 Dopamine Antagonist on Gambling Reinforcement in Pathological Gamblers and Healthy Controls
Authors: Kalia, Aditi
Advisor: Zack, Martin
Department: Pharmacology
Keywords: dopamine
pathological gambling
addiction
haloperidol
fluphenazine
dopamine antagonist
Issue Date: 12-Dec-2011
Abstract: Pathological Gambling (PG) is an impulse control disorder with lifetime prevalence of 1-3%. Available treatments are limited by uncertain classification and complexity of implicated neurotransmitter systems. Dopamine (DA), a key neurotransmitter implicated in addictive behavior and reward is elevated in response to gambling and psychostimulants. Based on previous research, it was hypothesized that the D2 blocker, haloperidol (HAL), will enhance slot machine reinforcement in PG but not in Healthy Controls (HC). If this increase reflects preferential stimulation of D1 receptors and group differences in D1 sensitivity, D1-D2 blocker (fluphenazine, FLU) should offset increase in reinforcement seen with HAL in PG subjects. In line with DA's implicated role in 'wanting' vs. 'liking' of the addictive reinforcer, the results suggest that DA release mediated partial D1 activation under FLU led to clear differentiation between groups with increased 'wanting' seen in controls but not in gamblers. DA's role in 'liking' however remains elusive.
URI: http://hdl.handle.net/1807/31270
Appears in Collections:Master

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