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|Title: ||Serum Estradiol Levels and Mental Health-related Quality of Life in Canadian Postmenopausal Women: A Cross-sectional Study|
|Authors: ||Mansfield, Joanna|
|Advisor: ||Cheung, Angela M.|
|Department: ||Health Policy, Management and Evaluation|
|Keywords: ||Serum Estradiol|
Health-Related Quality of Life
|Issue Date: ||14-Dec-2011|
|Abstract: ||Background: Serum estradiol levels decline after menopause and the effect on mental health-related quality of life (MHR-QOL) is unclear.
Objective: To determine if there is an association between endogenous serum estradiol levels and MHR-QOL in healthy postmenopausal women.
Methods: This cross-sectional study used baseline Canadian data from the Mammary Prevention.3 trial. Serum estradiol was measured with liquid chromatography-tandem mass spectrometry. Outcomes for MHR-QOL were the Medical Outcomes 36-Item Short Form Health Survey (SF-36) Mental Health Inventory-5 (MHI-5), Mental Component Summary (MCS), and the Menopause-Specific Quality of Life Questionnaire (MENQOL)-psychosocial domain.
Results: There were no statistically significant associations between estradiol levels and MHR-QOL in univariate analyses (n=455). Multivariable linear regression predicted statistically significant differences in MCS (R2=0.10, P=0.03) and MENQOL-psychosocial domain (R2=0.10, P=0.04), however estradiol was not a significant predictor.
Conclusions: This study did not find a statistically significant association between endogenous serum estradiol levels and MHR-QOL in healthy postmenopausal women.|
|Appears in Collections:||Master|
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