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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/31421

Title: Uncoupling of Endothelial Nitric Oxide Synthase after Subarachnoid Hemorrhage
Authors: Attia, Mohammed
Advisor: Macdonald, Robert Loch
Department: Medical Science
Keywords: eNOS
Subarachnoid hemorrhage
Oxidative stress
Stroke
Nitric oxide
Issue Date: 20-Dec-2011
Abstract: Subarachnoid hemorrhage (SAH) comprises 7% of all stroke cases, and is associated with a disproportionately high morbidity and mortality with few therapeutic options available. The goal of this project was to understand the mechanism of neurological deterioration after experimental SAH, with a focus on cerebral vasospasm and brain injury after SAH. We tested the hypothesis that endothelial nitric oxide synthase (eNOS) is upregulated and uncoupled after SA, resulting in exacerbated neurological injury in a mouse model of SAH. The project entailed the investigation of eNOS-dimer uncoupling, its association with oxidative and nitrosative stress in the brain parenchyma and finally its association with secondary complications after SAH. In our studies we demonstrated the crucial role eNOS plays in anti-microthromboembolism, anti-apoptosis and maintenance of physiological superoxide (O2-)/NO balance. This study suggests that SAH up-regulates and disrupts eNOS, producing peroxynitrite (OONO-) and other radicals that further exacerbate the oxidative insult and neurological injury.
URI: http://hdl.handle.net/1807/31421
Appears in Collections:Master

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