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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/31634

Title: Dissecting The Role Of TNFα In Kawasaki Disease: Alteration Of Cell Fate By TNFα After Superantigen Activation
Authors: Wong, Aaron
Advisor: Yeung, Rae S. M.
Department: Immunology
Keywords: Kawasaki Disease
Issue Date: 4-Jan-2012
Abstract: Kawasaki disease (KD) is an acute inflammatory disease characterized by persistent inflammation of the coronary arteries. KD is characterized by the release of cytokines such as tumor necrosis factor alpha (TNFα) and is thought to be initiated by a superantigen (SAg). The Lactobacillus casei cell wall extract model of KD demonstrates a critical requirement for TNFα and its receptor during pathogenesis, although the precise effect of TNFα is unknown. A persistent T cell infiltrate in the coronary artery disagrees with established fates of SAg activated cells, which undergo apoptosis. In this work, TNFα was found to promote the survival of SAg-reactive T cells. The results demonstrate that TNFα regulates B7.2 molecule expression on antigen presenting cells, and that TNFα indirectly promotes the survival of SEB-stimulated T cells by driving costimulation. These observations demonstrate how TNFα prevents T cell apoptosis and lend support to KD therapies which target TNFα and B7.
URI: http://hdl.handle.net/1807/31634
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