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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/31656

Title: Hypothalamic AMP-activated Protein Kinase Regulates Glucose Production
Authors: Yang, Shuo
Advisor: Lam, Tony K. T.
Department: Physiology
Keywords: Diabetes
Nutrient Sensing
Hypothalamic AMPK
Glucose Production
Issue Date: 4-Jan-2012
Abstract: Hypothalamic AMP-activated protein kinase (AMPK) regulates energy homeostasis in response to nutritional and hormonal signals. However, its role in glucose production regulation remains to be elucidated. Here, we tested the hypothesis that bidirectional changes in hypothalamic AMPK activity alter glucose production in rodents. First, we found that knocking down hypothalamic AMPK activity in an in vivo rat model led to a significant suppression of glucose production independent of changes in food intake and body weight. Second, we showed that activation of hypothalamic AMPK negated the ability of hypothalamic glucose- and lactate- sensing to lower glucose production. Collectively, these data indicate that changes in hypothalamic AMPK activity are sufficient and necessary for hypothalamic nutrient-sensing mechanisms to alter glucose production in vivo, and highlight the novel role of hypothalamic AMPK in the maintenance of glucose homeostasis in addition to energy balance.
URI: http://hdl.handle.net/1807/31656
Appears in Collections:Master

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