T-Space at The University of Toronto Libraries >
UofT faculty publications >
UofT Faculty publications >
Please use this identifier to cite or link to this item:
|Title: ||Function and Health Status Outcomes Following Soft Tissue Reconstruction for Limb Preservation in Extremity Soft Tissue Sarcoma|
|Authors: ||Davidge, K|
|Keywords: ||Function and Health Status Outcomes Following Soft Tissue Reconstruction for Limb Preservation in Extremity Soft Tissue Sarcoma|
|Issue Date: ||Jan-2010|
|Publisher: ||Annals of Surgical Oncology|
|Citation: ||Annals of Surgical Oncology 2010;17:1052-1062|
|Abstract: ||Background. While advances in reconstructive surgery have facilitated limb preservation in extremity soft tissue sarcoma (ESTS), limited information exists as to the
functional outcome of patients with these reconstructed extremities. The primary objective of this study is to
evaluate the impact of flap reconstruction on postoperative function and health status in patients undergoing limbsalvage
surgery for ESTS.
Methods. Clinical and outcome data for eligible patients were extracted from a prospectively maintained database of
sarcoma patients. Four outcome measures were used to assess three domains of function (impairments, activity limitations, and participation restrictions), and health status. The effect of soft tissue reconstruction on function and
health status at 1–2-year follow-up was analyzed using univariate and multivariate regression.
Results. Two hundred and forty-seven patients met eligibility
criteria, including 56 patients receiving flap reconstruction and 191 patients treated with primary closure. Patients receiving flaps had larger (9.8 versus 7.1 cm;
P = 0.003), higher-grade (93% versus 72%; P = 0.001)tumors, and more frequently received radiotherapy (89% versus 72%; P = 0.007), and bone (20% versus 4%; P = 0.001) and motor nerve resection (21% versus 10%;
P = 0.032). Flap reconstruction was associated with more postoperative impairments [Musculoskeletal Tumor Society
(MSTS) score 30.4 versus 32.2; P = 0.004] and
activity limitations [Toronto Extremity Salvage Score (TESS) score 83.3 versus 89.5; P = 0.0132] on univariate analyses, but did not significantly predict postoperative
function or health status outcomes on multivariate analyses.
Conclusions. Flap reconstruction was not an independent predictor of function and health status outcomes in patients with ESTS. However, ESTS patients receiving flaps had
other clinical features placing them at risk for worse postoperative outcomes.|
|Appears in Collections:||UofT Faculty publications|
Items in T-Space are protected by copyright, with all rights reserved, unless otherwise indicated.