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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/32224

Title: Possible Role of Osteoblasts in Regulating the Initiation of Endochondral Repair Process during Fracture Healing
Authors: Amani Andabili, Yasha
Advisor: Alman, Benjamin
Miller, Freda
Department: Laboratory Medicine and Pathobiology
Keywords: Fracture repair
Endochondral Ossification
Osteoblast
Osteoclast
Chondrocyte
Herpes simplex virus thymidine kinase
Gacnciclovir
Issue Date: 21-Mar-2012
Abstract: Fracture repair is a regenerative event that involves the precise coordination of a variety of cells for successful healing process. Within the microstructure hierarchy of bone repair, the predominant cells involved include the chondrocytes, osteocytes, osteoblasts, and osteoclasts. Although the role of osteoblasts during fracture healing has been previously shown, their role during the initiation phase of endochondral fracture repair remains unclear. In order to study the role of osteoblasts during fracture repair, we used a transgenic mouse model expressing the herpes simplex virus thymidine kinase gene in early differentiating osteoblasts, which allows conditional ablation of cells in osteoblastic lineage upon treatment with the Gancicolvir drug. Results from this study suggest that not only are osteoblasts required in later stages of fracture repair as the medium for bone synthesis, and osteoclast activation during bone remodelling, but could also be required for the initiation and advancement of the endochondral ossification process.
URI: http://hdl.handle.net/1807/32224
Appears in Collections:Master

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