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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/32274

Title: Angiopoietin-1 and -2 in Infectious Diseases associated with Endothelial Cell Dysfunction
Authors: Page, Andrea Vaughn
Advisor: Liles, W. Conrad
Department: Medical Science
Keywords: angiopoietin-1
angiopoietin-2
endothelial cell
streptococcal toxic shock
hemolytic-uremic syndrome
sepsis
Issue Date: 21-Mar-2012
Abstract: Normal endothelial cell function is controlled in part by a tightly regulated balance between angiopoietin-1 and -2 (Ang-1 and Ang-2). Angiopoietin dysregulation (decreased Ang-1 and increased Ang-2) leads to an activated endothelium that is contractile, adhesive, and prothrombotic. Since an activated endothelial phenotype is seen in invasive group A streptococcal infection, E. coli O157:H7-induced hemolytic-uremic syndrome (HUS), and sepsis, we hypothesized that angiopoietin dysregulation might also be present in these syndromes, and to that end, measured angiopoietin levels in several well-characterized patient cohorts. Decreased Ang-1 and/or increased Ang-2 were found in all three syndromes, and were predictive of clinical outcome in HUS and sepsis. The prognostic utility of Ang-2 in sepsis was further enhanced by combination with biomarkers of inflammation. Angiopoietin dysregulation may therefore represent a shared final common pathway to endothelial activation as well as a clinically useful prognostic biomarker in streptococcal toxic shock, HUS, and sepsis.
URI: http://hdl.handle.net/1807/32274
Appears in Collections:Master

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