test Browse by Author Names Browse by Titles of Works Browse by Subjects of Works Browse by Issue Dates of Works
       

Advanced Search
Home   
 
Browse   
Communities
& Collections
  
Issue Date   
Author   
Title   
Subject   
 
Sign on to:   
Receive email
updates
  
My Account
authorized users
  
Edit Profile   
 
Help   
About T-Space   

T-Space at The University of Toronto Libraries >
School of Graduate Studies - Theses >
Master >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/32486

Title: Patients’ Preferences and Trade Offs for the Treatment of Small Hepatocellular Carcinomas
Authors: Molinari, Michele
Advisor: Urbach, David Robert
Department: Health Policy, Management and Evaluation
Keywords: Hepatocellular Carcinoma
Radiofrequency Ablation
Hepatic Resection
Cirrhosis
Patient's Preferences
Perioperative Risks
Treatment Benefits
Probabiltity Trade-off
Issue Date: 23-Jul-2012
Abstract: Objective: The primary aim of this study was to assess patients’ preferences between radiofrequency ablation (RFA) versus hepatic resection (HR) for the treatment of small hepatocellular carcinomas (HCC). Methods: Decision analysis was performed by using probability trade-off (PTO) technique to elicit patients’ preferences and the strength of their decisions. Results: The vast majority of the study population preferred RFA over HR (70% vs. 30%, p=0.001). Their initial choice changed if 5-year survival benefit after surgery was at least 14% superior to RFA and if the 3-year disease-free survival advantage was at least 13% better than ablation. Conclusions: The results of this study suggest that fully informed cirrhotic patients would prefer RFA if diagnosed with early stage HCC even if able to undergo surgery.
URI: http://hdl.handle.net/1807/32486
Appears in Collections:Master

Files in This Item:

File Description SizeFormat
Molinari_Michele_201206_MSc_thesis.pdf1.6 MBAdobe PDF
View/Open

Items in T-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

uoft