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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/32620

Title: Application of Vertical-cavity Surface-emitting Lasers for Simultaneous Laser Speckle Contrast and Intrinsic Optical Signal Imaging: Toward Chronic Portable Cortical Hemodynamic Imaging
Authors: Ringuette, Dene
Advisor: Levi, Ofer
Department: Biomedical Engineering
Keywords: biophotonics
hemodynamics
imaging
speckle
optics
ischemia
vcsel
coherence
Issue Date: 15-Aug-2012
Abstract: We demonstrated simultaneous intrinsic optical signal imaging (IOSI) and laser speckle contrast imaging (LSCI) using coherence modulation of vertical-cavity surface-emitting laser (VCSEL) diodes. The unique properties of VCSELs were exploited to deliver rapidly switched coherent and non-coherent illumination suitable for high resolution LSCI and IOSI, respectively. Utilizing three near-infrared VCSELs we were able to map changes in cortical blood oxygenation and flow during ischemia. Additionally, the subtle reflectance changes associated with cortical spreading depression were imaged using non-coherent VCSEL illumination. We are currently using two-photon laser-scanning microscopy to quantify the accuracy of LSCI and IOSI implementations. The small size and efficiency of VCSELs and modern photo diodes, makes the development of implantable dual-mode imaging devices feasible. Devices capable of chronic imaging of cortical hemodynamics could significantly enhance the range of studies available to neuroscientists and significantly aid clinicians postoperatively. The research presented in this thesis significantly furthers this objective.
URI: http://hdl.handle.net/1807/32620
Appears in Collections:Master

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