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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/33443

Title: Cost-effectiveness of Intermittent versus Continuous Androgen Deprivation Therapy in Advanced Prostate Cancer
Authors: Maturi, M. Brigida
Advisor: Krahn, Murray
Department: Pharmaceutical Sciences
Keywords: Economic evaluation
cost-effectiveness
prostate cancer
Issue Date: 22-Nov-2012
Abstract: Background: Androgen deprivation therapy (ADT) has known adverse effects (AEs). Intermittent (INT) ADT may reduce AEs, improve quality of life, and lower costs compared to continuous (CONT) treatment. Objective: To evaluate the cost-effectiveness of INT vs CONT ADT in men with advanced prostate cancer. Methods: A lifetime Markov individual simulation model was developed to evaluate the incremental cost per quality adjusted life month (QALM) of INT vs CONT ADT. Results: INT dominated CONT ADT (mean total costs $94,460 vs $109,431; mean total QALMs 47.0 vs 46.4). INT ADT resulted in less time on therapy (22.4 vs 56.8 months), fewer hip fractures (0.080 vs 0.093 per patient), and fewer total cases of sexual dysfunction (72.5% vs 87.0% of patients) and cardiovascular disease (38.7% vs 44.6% of patients). Conclusions: These results suggest INT ADT is cost-effective compared to CONT ADT however, differences were small. Additional research is required to confirm these findings.
URI: http://hdl.handle.net/1807/33443
Appears in Collections:Master

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