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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/33460

Title: Design of an Electrochemical Cell Cytosensor
Authors: Moscovici, Mario
Advisor: Kelley, Shana O.
Department: Biomedical Engineering
Keywords: Engineering
Biomedical
Issue Date: 22-Nov-2012
Abstract: A sensitive and simple cell counting method is necessary in many pathologies including HIV [1] and cancer [2]. Cell counting sensors are used in the clinic for diagnosis of leukemia [3] or HIV [4]. Furthermore, genetic analysis of these cells is crucial for better prognosis and diagnosis [5]. However, a simple method for cell counting that allows further analysis is still lacking. This study aims to design a sensor that counts cells in the complex matrix of cell media or in the presence of non-target cells. The chip designed uses the anti-EpCAM antibody to selectively count cells via differential pulse voltammetry. The device can selectively count prostate cancer cells in both complex media with serum and a mixed cell population with a sensitivity of 125 cells per sensor. A simple and sensitive cell cytosensor was designed that can be used to count cancer cells effectively.
URI: http://hdl.handle.net/1807/33460
Appears in Collections:Master

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