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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/33702

Title: Saccade Related Gamma Potentials Recorded in Human Subthalamic Nucleus, Globus Pallidus Interna and Ventrointermediate Nucleus of the Thalamus
Authors: Sundaram, Arun N. E.
Advisor: Sharpe, James
Hutchison, William D.
Department: Medical Science
Keywords: Gamma oscillations
Saccadic Spike potentials
Local field potential oscillations
Deep brain stimulation
Gamma artifact
Subthalamic nucleus
Globus pallidus interna
Ventrointermediate nucleus
Issue Date: 3-Dec-2012
Abstract: Gamma oscillations of local field potentials (LFP) in the basal ganglia and thalamus had not been studied during saccades. Eleven patients were studied during deep brain stimulation (DBS); 6 were in the subthalamic nucleus (STN); 3 in the globus pallidus interna (GPi); and 2 in the thalamic ventralis intermedius nucleus (Vim). Patients performed horizontal saccades to visual targets while LFPs from DBS electrodes, scalp electroencephalogram (EEG), and electrooculogram (EOG) were recorded. Wavelet spectrograms were generated and saccade onset and event-related gamma synchronizations (ERS) were compared to baseline without eye motion. ERS were recorded at and after saccade onset in the STN, GPi and Vim, EEGs and EOGs; but were absent during target light illumination without saccades. ERS were symmetric in all DBS contacts and appeared identical in DBS LFPs, frontal EEGs and EOGs. These findings indicate their origin from extraocular muscle spike potentials rather than brain neural activity.
URI: http://hdl.handle.net/1807/33702
Appears in Collections:Master

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