test Browse by Author Names Browse by Titles of Works Browse by Subjects of Works Browse by Issue Dates of Works
       

Advanced Search
Home   
 
Browse   
Communities
& Collections
  
Issue Date   
Author   
Title   
Subject   
 
Sign on to:   
Receive email
updates
  
My Account
authorized users
  
Edit Profile   
 
Help   
About T-Space   

T-Space at The University of Toronto Libraries >
School of Graduate Studies - Theses >
Master >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/33703

Title: Urinary Composition and Stone Formation
Authors: Shafiee, Mohammad Ali Jr.
Advisor: Logan, Alexander
Department: Medical Science
Keywords: Nephrology
Medical Science
Issue Date: 3-Dec-2012
Abstract: Background: Kidney stone disease is a common and often debilitating disorder, yet its pathophysiology is poorly understood. This dissertation studies predisposition to kidney stone formation from diurnal variation in physiochemical and physiologic properties of urine and in response to increased fluid intake. Methods: Urine volume, flow rate and constituents were measured in multiple timed specimens from healthy volunteers in a day. Further, subjects were asked to provide specimen over a period of increased fluid intake. Results: A 24-hour specimen missed significant periods of supersaturation in individual urine samples throughout the day. Despite a significant reduction in nocturnal urine flow rate, calcium concentration as well as urine pH and divalent phosphate remained unchanged. Finally, increased water intake did not dilute urine evenly. Conclusion: Mixing multiple urine samples obscures information about periods of increased calcium phosphate precipitation risk over 24 hours. Further, increased fluid intake does not uniformly provide risk protection.
URI: http://hdl.handle.net/1807/33703
Appears in Collections:Master

Files in This Item:

File Description SizeFormat
Shafiee_Mohammad_Ali_201011_MSc_thesis.pdf1.18 MBAdobe PDF
View/Open

This item is licensed under a Creative Commons License
Creative Commons

Items in T-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

uoft