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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/33714

Title: Intestinal Cholecystokinin Controls Glucose Production through a Neuronal Network
Authors: Cheung, Wing Chee
Advisor: Lam, Tony K. T.
Department: Physiology
Keywords: gut
CCK
Issue Date: 3-Dec-2012
Abstract: Cholecystokinin (CCK) is a gut peptide involved in the regulation of energy homeostasis by duodenal lipids via a neuronal network. However, it is unknown whether CCK also regulates glucose homeostasis through a neuronal network. Using an in vivo rat model, we demonstrated that duodenal CCK-8 (biologically active form of CCK) can lower glucose production through the activation of a gut-brain-liver axis via CCK-A receptors, and this glucose-regulatory effect is physiologically relevant. Since duodenal lipids can also lower glucose production through a gut-brain-liver axis, we verified that this duodenal-lipid effect is mediated by CCK-A receptor activation. Lastly, in rats fed on a high-fat diet for three days, duodenal CCK failed to suppress glucose production, suggesting a state of CCK-resistance. In summary, these findings revealed that intestinal CCK can regulate glucose homeostasis through a neuronal network and suggest that intestinal CCK resistance may contribute to hyperglycemia in response to high-fat feeding.
URI: http://hdl.handle.net/1807/33714
Appears in Collections:Master

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