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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/33867

Title: A Newborn Sex-related Response to Hyperoxia
Authors: Tan, Luke
Advisor: Wittnich, Carin
Department: Physiology
Keywords: Hyperoxia
Hemodynamics
sex-difference
Issue Date: 6-Dec-2012
Abstract: Exposure to hyperoxia has been shown to have detrimental effects on newborn hemodynamics and antioxidant activities in males. These effects are unknown in the newborn female, despite clinical data showing that in children undergoing surgery females have poorer outcomes. This thesis explored whether newborn females respond worse than males to hyperoxia, specifically in hemodynamics and antioxidant activity. Hemodynamic results showed continual decreases in DBP and MAP, increases in HR, decreases in SBP, and increases in PP, which were experienced earlier and to a greater degree in the female. Additionally, reduced antioxidant activity seen in newborns was worse in females in both the heart and skeletal muscle. These results suggest that in response to hyperoxia, newborn females are at a hemodynamic disadvantage when compared to males, which may be a contributing factor for why female children are at a higher risk during surgery or medical management involving hyperoxia.
URI: http://hdl.handle.net/1807/33867
Appears in Collections:Master

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