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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/348

Title: Trapping-induced changes in expression of the N-methyl-d-aspartate receptor in the hippocampus of snowshoe hares
Authors: Boonstra, Rudy
Takagi, Norio
Bissoon, Nankie
Vij, Shilpa
Gurd, James W.
Keywords: N-methyl-d-aspartate receptor
Natural populations
Snowshoe hare
Issue Date: 2002
Publisher: Elsevier Science Ireland Ltd.
Citation: Neuroscience Letters 324 (2002) 173–176
Abstract: Live-trapping of animals in natural populations is one of the main ways to determine population processes. We examined the effects of live-trapping on the expression of N-methyl-d-aspartate (NMDA) receptor subunits in the hippocampus of snowshoe hares. Snowshoe hares were obtained either with or without the stress of live-trapping. The CA1, CA3 and dentate gyrus were dissected and analyzed for the presence of NMDA receptor subunits. Trapping resulted in a significant reduction of NMDA receptor 1 (NR1) in each of the regions examined but did not affect the levels of either NMDA receptor 2A or B (NR2A or NR2B). Co-immunoprecipitation analysis showed that the association between NR1 and NR2A was decreased in the trapped animals. These results suggest that stress associated with the trapping experience may adversely affect the structure and/or function of the NMDA receptor. q 2002 Elsevier Science Ireland Ltd. All rights reserved.
URI: http://hdl.handle.net/1807/348
Appears in Collections:Biology

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