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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/3572

Title: Cytokine Profile Associated with Human Chronic Schistosomiasis Mansoni
Authors: Magalhães, Andréa
Miranda, Delfin Gonzalez
Miranda, Roberval Gonzalez
Araújo, Maria Ilma
Almeida de Jesus, Adriana
Silva, Angela
Santana, Luciana B.
Pearce, Edward
Carvalho, Edgar M.
Ribeiro de Jesus, Amélia
Keywords: Tropical Diseases
schistosomiasis - hepatic fibrosis - interleukin-5 - interleukin-13 oc04081
Issue Date: Aug-2004
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz 99(s1)
Abstract: This study objective was to evaluate the cytokines associated with early events of hepatic fibrosis in schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography in 94 patients. Immunological evaluation was performed by measurement of secreted cytokines (interleukin IL-5, IL-10, IL-13, interferon-γ, tumor necrosis factor-α and transforming growth factors-β) in peripherl blood mononuclear cells stimulated by Schistosoma mansoni antigens. Significantly, higher levels of IL-5, IL-10 and IL-13 were found in supernatants of SEA-stimulated PBMC from subjects with degree III hepatic fibrosis as compared to patients with degree I or II fibrosis, Significant increases in IL-5 and IL-13 levels were also observed in some of the subjects who remained untreated for one year following initial assessment and developed more serious fibrosis during this period. The data suggests a role for type 2 cytokines in early stages of hepatic fibrosis in human schistosomiasis mansoni.
URI: http://bioline.utsc.utoronto.ca/archive/00002425/03/oc04081.pdf
Other Identifiers: http://bioline.utsc.utoronto.ca/archive/00002425/
Appears in Collections:Bioline International Legacy Collection

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