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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/3722

Title: GB virus C/hepatitis G virus infection in dialysis patients and kidney transplant recipients in Central Brazil
Authors: Filho, Ramon Ramos
Carneiro, Megmar A. S.
Teles, Sheila A.
Dias, Márcia A.
Cardoso, Divina D. P.
Lampe, Elisabeth
Yoshida, Clara F. T.
Martins, Regina M. B.
Keywords: Tropical Diseases
hepatitis G virus - GB virus C - dialysis - kidney transplant - Central Brazil oc04133
Issue Date: Oct-2004
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz 99(6)
Abstract: In order to investigate the prevalence of GB virus C (GBV-C)/hepatitis G virus (HGV) infection in dialysis patients and kidney transplant recipients in Central Brazil and also to analyze the virus genotypes distribution, a total of 123 patients including 98 on hemodialysis, 13 on continuous ambulatory peritoneal dialysis treatment, and 12 who received kidney transplantation were interviewed in one unit of dialysis treatment in Goiânia city. Blood samples were collected and serum samples tested for GBV-C/HGV RNA by polymerase chain reaction. Genotypes were determined by restriction fragment length polymorphism (RFLP) analysis. Eighteen samples were GBV-C/HGV RNA-positive, resulting in an overall prevalence of 14.6% (95% CI: 9.2-21.7). A high positivity for GBV-C/HGV RNA was observed in patients who had received kidney transplant (16.7%), followed by those on hemodialysis (15.3%), and peritoneal dialysis (7.7%). RFLP analysis revealed the presence of genotypes 1, 2, and 3 of GBV-C/HGV; more precisely, 9 (50%) samples were found belonging to the 2b subtype, 4 (22%) to the 2a subtype, 3 (17%) to genotype 1, and 2 (11%) to genotype 3. The present data indicate an intermediate prevalence of GBV-C/HGV infection among dialysis patients and kidney transplant recipients in Central Brazil. Genotype 2 (subtype 2b) seems to be the most prevalent GBV-C/HGV genotype in our region.
URI: http://bioline.utsc.utoronto.ca/archive/00002580/01/oc04133.pdf
Other Identifiers: http://bioline.utsc.utoronto.ca/archive/00002580/
Appears in Collections:Bioline International Legacy Collection

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