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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/3724

Title: Cytotoxicity of Three New Triazolo-pyrimidine Derivatives against the Plant Trypanosomatid: Phytomonas sp. Isolated from Euphorbia characias
Authors: Magán, Rosa
Marín, Clotilde
Salas, Juan M.
Barrera-Pérez, Mario
Rosales, Maria J.
Sánchez-Moreno, Manuel
Keywords: Tropical Diseases
Microbiology
Phytomonas sp. - triazolo-pyrimidine complexes - chemotherapeutic agents oc04135
Issue Date: Oct-2004
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz 99(6)
Abstract: There is no effective chemotherapy against diseases caused by Phytomonas sp., a plant trypanosomatid responsible for economic losses in major crops. We tested three triazolo-pyrimidine complexes [two with Pt(II), and another with Ru(III)] against promastigotes of Phytomonas sp. isolated from Euphorbia characias. The incorporation of radiolabelled precursors, ultrastructural alterations and changes in the pattern of metabolite excretion were examined. Different degrees of toxicity were found for each complex: the platinun compound showed an inhibition effect on nucleic acid synthesis, provoking alterations on the levels of mitochondria, nucleus and glycosomes. These results, together with others reported previously in our laboratory about the activity of pyrimidine derivatives, reflect the potential of these compounds as agents in the treatment of Phytomonas sp.
URI: http://bioline.utsc.utoronto.ca/archive/00002582/01/oc04135.pdf
http://hdl.handle.net/1807/3724
Other Identifiers: http://bioline.utsc.utoronto.ca/archive/00002582/
Appears in Collections:Bioline International Legacy Collection

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