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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/3735

Title: Darier's disease following radiotherapy for carcinoma of cervix
Authors: Chopra, Supriya
Sharma, Vinay
Nischal, K. C.
Khopkar, Uday
Baisane, Chanda
Amare, Pratibha
Keywords: Dermatology
Darier’s disease, Carcinoma cervix, Chromosomal aberrations, Cutaneous manifestations dv04103
Issue Date: Sep-2004
Publisher: Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
Citation: Indian Journal of Dermatology, Venereology and Leprology 70(5)
Abstract: Darier-White disease is due to a defect in the ATP2A2 gene encoding the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA2b). We report a case of carcinoma cervix in whom Darier's disease manifested after the initiation of radiation therapy. Conventional cytogenetics on peripheral blood revealed non-clonal constitutional autosomal and X chromosome abnormalities suggesting radiation induced gene toxicity. Occurrence of Darier's disease in our case could be due to treatment induced sustained differentiation in the Darier's affected skin by an unknown mechanism. Late onset or sporadic Darier's disease is the other possibility.
URI: http://bioline.utsc.utoronto.ca/archive/00002593/01/dv04103.pdf
Other Identifiers: http://bioline.utsc.utoronto.ca/archive/00002593/
Appears in Collections:Bioline International Legacy Collection

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