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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/3948

Title: Calcium channel blockers reduce inflammatory edema in the rat: involvement of the hypothalamus-pituitary-adrenal axis
Authors: Khaksari, M.
Mahani, S. E.
Mahmoodi, M.
Keywords: Pharmacology
Acute inflammation, adrenalectomy, carrageenan ph04126
Issue Date: Nov-2004
Publisher: Medknow Publications on behalf of Indian Pharmacological Society
Citation: Indian Journal of Pharmacology 36(6)
Abstract: OBJECTIVE: To evaluate the role of calcium channel blockers and their mechanisms of action on acute inflammation of rat paw. MATERIAL AND METHODS: The study was conducted using carrageenan-induced rat paw inflammation model. Two different doses of nifedipine and verapamil (25 and 400 µg/kg, i.p.) were used. Edema was assessed by calculating the volume changes and by extravasation of Evans blue dye. RESULTS: Nifedipine reduced edema dose-dependently, whereas verapamil was effective only at low dose. Adrenalectomy prevented the effect of nifedipine and verapamil. With low dose of nifedipine 66% of antiinflammatory effect was observed. Pretreatment with a-helical corticotropin releasing factor (CRF 9-41), a corticotropin-releasing hormone (CRH) receptor antagonist, had the same effect as that of adrenalectomy for either doses of verapamil, but only the effect of low-dose nifedipine was prevented completely. CONCLUSION: Our data suggest that verapamil and nifedipine exerts a potent antiinflammatory action possibly through pituitary adrenocortical activation.
URI: http://bioline.utsc.utoronto.ca/archive/00002809/01/ph04126.pdf
Other Identifiers: http://bioline.utsc.utoronto.ca/archive/00002809/
Appears in Collections:Bioline International Legacy Collection

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