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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/3975

Title: Warfarin-induced necrosis of the breast: case report
Authors: Khalid, K.
Keywords: Medicine
warfarin, necrosis, breast jp04092
Issue Date: Oct-2004
Publisher: Medknow Publications and Staff Society of Seth GS Medical College and KEM Hospital, Mumbai, India
Citation: Journal of Postgraduate Medicine 50(4)
Abstract: Warfarin-induced necrosis of the breast is an unusual complication of warfarin therapy. Since its first description in 1943, up to 36 cases have been reported in the English literature. Close association between inherited or functional deficiency of protein C and S and warfarin therapy is frequently reported. A characteristic patient is an obese middle-aged female receiving anticoagulant treatment. The rapidly evolving painful lesion appears suddenly, usually within 3 to 6 days after initiation of warfarin therapy. Prevention may be achieved by identifying the high-risk patients–female gender, middle age, obesity, and avoiding large loading doses of warfarin. Early recognition and treatment are necessary to avoid significant long-term morbidity. Established necrosis necessitates debridement and sometimes mastectomy. A case of warfarin-induced necrosis of the left breast mimicking inflammatory cancer is reported. Current recommendations for the prevention and treatment of this uncommon condition are reviewed.
URI: http://bioline.utsc.utoronto.ca/archive/00002836/01/jp04092.pdf
http://hdl.handle.net/1807/3975
Other Identifiers: http://bioline.utsc.utoronto.ca/archive/00002836/
Appears in Collections:Bioline International Legacy Collection

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