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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/4280

Title: Expression of SC1 is associated with the migration of myotomes along the dermomyotome during somitogenesis in early mouse embryos
Authors: Ringuette, Maurice
Rogers, Ian
Varmuza, Suzanna
Rush, Sheila
Brown, Ian R.
Keywords: SC1; Myotome expression; Matrix glycoprotein
Issue Date: 1998
Publisher: Springer-Verlag
Citation: Dev Genes Evol (1998) 208:403-406
Abstract: SC1 is a secreted glycoprotein with a high amino acid sequence similarity to SPARC (Secreted Protein, Acidic, Rich in Cysteine). SC1 transcripts were first detected in mouse embryos after day 8.5 post coitus (p.c.) in somites at the medial lip of the dermomyotome. Expression of SC1 transcripts by the progenitor cells continued as they began involuting under the dermomyotome and during their migration along the lateral wall of the dermomyotome. After myotome migration was completed, SC1 mRNA expression was downregulated in the trunk region. The data indicate that SC1 expression is restricted to the initial stages of epaxial myotome differentiation and migration, undergoing rapid downregulation prior to myotome emigration from the somitic environment.
URI: http://hdl.handle.net/1807/4280
Appears in Collections:Biology

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