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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/4283

Title: Induction of Hsp27 and Hsp32 stress proteins and vimentin in glial cells of the rat hippocampus following hyperthermia
Authors: Bechtold, David A.
Brown, Ian R.
Keywords: Hyperthermia ; Hsp27 ; Hsp32 ; heat shock protein ; vimentin ; astrocytes ; microglia
Issue Date: 2003
Publisher: Kluwer Academic/Plenum Publishers
Citation: Neurochemical Research, Vol. 28, No. 8. August 2003. pp. 1163-1174
Abstract: In response to stressful stimuli, cells respond by inducing a set of heat shock (stress) proteins (hsps) that play important roles in repair and protective mechanisms. The present study investigates the expression patterns of Hsp27 and Hsp32 in the adult rat hippocampus following whole body hyperthermia. A pronounced induction of these low-molecular-weight stress proteins was apparent in populations of glial cells such as astrocytes and microglia that were identified Using cell-specific markers (GFAP for astrocytes and the lectin GSA I-B4 for microglia). Hyperthermia also resulted in a robust induction of the intermediate filament protein, vimentin, in glial cells in the adult rat hippocampus. Interestingly, a rapid induction of both Hsp27 and vimentin was observed in the microvasculature, suggesting that hyperthermic stress may compromise the blood-brain barrier.
URI: http://hdl.handle.net/1807/4283
Appears in Collections:Biology

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