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|Title: ||Atypical antipschotic drugs and risk of ischemic storke: population based retrospective cohort study|
|Authors: ||Gill, S.S.|
Normand, S-L. T.
|Issue Date: ||Jan-2005|
|Publisher: ||BMJ Publishing Group Limited|
|Abstract: ||Objective To compare the incidence of admissions to hospital
for stroke among older adults with dementia receiving atypical
or typical antipsychotics.
Design Population based retrospective cohort study.
Setting Ontario, Canada.
Patients 32 710 older adults ( ≥ 65 years) with dementia (17 845
dispensed an atypical antipsychotic and 14 865 dispensed a
Main outcome measures Admission to hospital with the most
responsible diagnosis (single most important condition
responsible for the patient’s admission) of ischaemic stroke.
Observation of patients until they were either admitted to
hospital with ischaemic stroke, stopped taking antipsychotics,
died, or the study ended.
Results After adjustment for potential confounders,
participants receiving atypical antipsychotics showed no
significant increase in risk of ischaemic stroke compared with
those receiving typical antipsychotics (adjusted hazard ratio
1.01, 95% confidence interval 0.81 to 1.26). This finding was
consistent in a series of subgroup analyses, including ones of
individual atypical antipsychotic drugs (risperidone, olanzapine,
and quetiapine) and selected subpopulations of the main
Conclusion Older adults with dementia who take atypical
antipsychotics have a similar risk of ischaemic stroke to those
taking typical antipsychotics.|
|Appears in Collections:||Walter Wodchis |
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