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|Title: ||Longitudinal effects of botox injections on voice-related quality of life (V-RQOL) for patients with adductory spasmodic dysphonia (part II)|
|Authors: ||Rubin, A|
Wodchis, Walter P
Kileny, P R
Hogikyan, N D
|Issue Date: ||Dec-2001|
|Publisher: ||American Medical Association|
|Citation: ||Rubin, A., Wodchis, W.P., Spak, C., Kileny, P.R., Hogikyan, N.D. Longitudinal effects of botox injections on voice-related quality of life (V-RQOL) for patients with adductory spasmodic dysphonia: part II. Archives of Otolaryngology Head and Neck Surgery. 2004;130(4):415-420.|
|Abstract: ||Objective: To investigate the longitudinal effects of botulinum
toxin type A (Botox) injections on voice-related
quality of life (V-RQOL) for patients with adductory spasmodic
Design: Prospective study.
Setting: Academic tertiary care referral center.
Participants: Forty-two patients who presented to our
institution with dysphonia and were diagnosed as having
adductory spasmodic dysphonia during a 38-month
Intervention: Patients received Botox injections into
both thyroarytenoid muscles via the cricothyroid membrane.
The typical starting dose was 1.0 U per vocal fold.
If necessary, the dosage was adjusted in subsequent injections
to reduce adverse effects or to enhance duration
Main Outcome Measures: Patients filled out questionnaires,
including the V-RQOL Measure and a selfassessed
overall voice rating, before each injection. Postinjection
questionnaires were completed 6 to 8 weeks after
each treatment. Mean pretreatment and posttreatment
scores were calculated for each treatment.
Results: The number of treatments per patient ranged
from 1 to 7. Statistically significant improvements in mean
total and domain V-RQOL scores were calculated for every
injection (P.01) (no postinjection questionnaires
were available for the seventh injections). The magnitude
of the effect remained constant for later injections.
Eighty-two percent of the population recorded at least 1
category of improvement in overall self-assessed voice rating
with each injection.
Conclusions: Botox has a significant beneficial effect on
V-RQOL for at least 6 injection cycles. This study demonstrates
the efficacy of Botox for treating patients with
adductory spasmodic dysphonia and further illustrates
the usefulness and validity of the V-RQOL Measure in
evaluating patients with dysphonia.|
|Appears in Collections:||Walter Wodchis |
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