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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/5160

Title: Synergistic interaction between two linear inhibitors on a single enzyme: Vanadate and L-phenylalanine inhibition of rat liver alkaline phosphatase
Authors: Malomo, Sylvia O.
Olorunniji, Femi J.
Arise, Rotimi O.
Adebayo, Joseph O.
Adedsu, Olaniyi T.
Odutuga, Adewale A.
Keywords: alkaline phosphatase, synergistic inhibition
Issue Date: 31-Dec-2003
Publisher: Nigerian Society for Experimental Biology
Citation: Biokemistri (ISSN: 0795-8080) Vol 13 Num 1
Abstract: The combined effect of two linear inhibitors of rat liver alkaline phosphatase (ALP). vanadate (Van) and L-phenylalanine (L-phe) were studied using a modification of the common Yonetani-Theorell procedure proposed for studying synergistic inhibition. The modes of inhibition of ALP by Van and L-phe as analysed using the double reciprocal plots of the Michaelis-Menten equation were mixed and uncompetitive inhibition respectively. Analysis of the combined effect of the two inhibitors showed that their inhibitory effects were mutually enhanced. The mechanistic aspects and practical applications of the procedure are discussed.
URI: http://hdl.handle.net/1807/5160
Other Identifiers: http://www.bioline.org.br/abstract?id=bk03004
Rights: Copyright 2003 - Nigerian Society for Experimental Biology
Appears in Collections:Bioline International Legacy Collection

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