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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/5314

Title: Review Article - Tissue microarrays: Potential in the Indian subcontinent
Authors: Girish, Venkataraman
Vijayalakshmi, Ananthanaranayanan
Keywords: Tissue microarrays, histopathology
Issue Date: 31-Dec-2005
Publisher: Medknow Publications on behalf of Indian Cancer Society
Citation: Indian Journal of Cancer (ISSN: 0019-509X) Vol 42 Num 1
Abstract: Tissue microarrays (TMAs) are a means of combining hundreds of specimens of tissue on to a single slide for analysis simultaneously. The evolution of this technology to validate the results of cDNA microarrays has impacted tremendously in accurately identifying prognostic indicators significant in determining survival demographics for patients. TMAs can be generated from archival paraffin blocks, combined with sophisticated image analysis software for reading TMA immunohistochemistry, and a staggering amount of useful information can be generated in terms of the biomarkers useful in predicting patient outcome. There is a wide range of uses for the TMA technology including profiling of specific proteins in cancerous tissues and non-cancerous tissues. Given the wide variety of tissue resources available in India, investment in a dedicated TMA facility will be of immense use in the research arena in India. This review article discusses the basics of TMA construction, design, the software available for the analysis of this technology and its relevance to Indian scientists. A potential workflow structure for setting up a TMA facility is also included.
URI: http://hdl.handle.net/1807/5314
Other Identifiers: http://www.bioline.org.br/abstract?id=cn05003
Rights: Copyright 2005 Indian Journal of Cancer.
Appears in Collections:Bioline International Legacy Collection

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