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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/5942

Title: Cytogenetic causes for recurrent spontaneous abortions – an experience of 742 couples (1484 cases)
Authors: Dubey, S.
Chowdhury, M. R.
Prahlad, B.
Kumar, V.
Mathur, R.
Hamilton, S.
Kabra, M.
Menon, P. S. N.
Verma, I. C.
Keywords: Chromosomal abnormalities; reciprocal translocation; recurrent spontaneous abortion; Robertsonian translocation
Issue Date: 31-Dec-2005
Publisher: Medknow Publications on behalf of Indian Society of Human Genetics
Citation: Indian Journal of Human Genetics (ISSN: 0971-6866) Vol 11 Num 2
Abstract: BACKGROUND: First trimester pregnancy loss is a very common complication and a matter of concern for couples planning pregnancy. Balanced chromosomal rearrangements in either parent is an important cause of recurrent pregnancy loss particularly in the first trimester. AIMS: In this study an evaluation of the contribution of chromosomal anomalies in causing repeated spontaneous abortions was made. METHODS AND MATERIALS: A review of the cytogenetic data in 742 couples (1484 individuals) with recurrent spontaneous abortions who were examined for chromosomal aberrations in the period 1990-2003 is presented. Women who had at least two abortions, or spontaneous abortions preceded or followed by fetal deaths or birth of a malformed child, and patients who had recurrent spontaneous abortions (> 3) with normal live issue/s were studied. RESULTS: Chromosomal rearrangements were found in 31 individuals (2%). These abnormalities included 22 (2.9%) structural aberrations, 9 (1.2%) numerical anomalies. In addition to these abnormalities, 21 (3.2%) chromosomal variants were also found. CONCLUSION: Chromosomal analysis is an important etiological investigation in couples with repeated spontaneous abortions as it helps in genetic counseling and deciding about further reproductive options.
URI: http://hdl.handle.net/1807/5942
Other Identifiers: http://www.bioline.org.br/abstract?id=hg05021
Rights: Copyright 2005 Indian Journal of Human Genetics.
Appears in Collections:Bioline International Legacy Collection

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