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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/5948

Title: HLA-A allele frequency and haplotype distribution in the dravidian tribal communities of south India
Authors: Thomas, R.
Banerjee, M.
Keywords: Dravidian, HLA-A, haplotype, South India, Tribals
Issue Date: 31-Dec-2005
Publisher: Medknow Publications on behalf of Indian Society of Human Genetics
Citation: Indian Journal of Human Genetics (ISSN: 0971-6866) Vol 11 Num 3
Abstract: Background: The tribal communities of South India are considered to be the original inhabitants of the Indian sub-continent, belonging to the most primitive Dravidian speaking communities. These Dravidian speaking forest dwelling tribal populations have remained isolated from any intermingling with other non-tribal communities. Aims and Objectives: We propose to understand the evolutionary processes mediated by molecular, functional and immunological information based on human leukocyte antigen (HLA) genetic system. Material and Methods: The HLA-A diversity was analyzed in seven Dravidian tribal populations namely Malapandaram, Paniya, Kurichiya, Kanikkar, Adiya, Kattunaikka and Kuruma of Kerala, South India using the PCR-SSP method. The tribal communities were compared with a group comprising of random non-tribal Dravidian samples of southern India. Results: In the present study, 11 HLA-A alleles were identified in the South Indian population. The most frequent alleles included HLA-A*24, A*02, A*33 and *A11. HLA-A*24 had the highest frequency in all the tribal groups while, A*02 was the highest frequency allele in the RND group. The haplotype Cw*14-A*24 was present in all the populations. The three-locus haplotype B*52-Cw*14-A*24 was observed in all the populations except Kurichiya and Kanikkar. Conclusion: The study suggests that the RND population is highly diverse and more likely to have an admixed origin.
URI: http://hdl.handle.net/1807/5948
Other Identifiers: http://www.bioline.org.br/abstract?id=hg05027
Rights: Copyright 2005 Indian Journal of Human Genetics.
Appears in Collections:Bioline International Legacy Collection

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