test Browse by Author Names Browse by Titles of Works Browse by Subjects of Works Browse by Issue Dates of Works
       

Advanced Search
Home   
 
Browse   
Communities
& Collections
  
Issue Date   
Author   
Title   
Subject   
 
Sign on to:   
Receive email
updates
  
My Account
authorized users
  
Edit Profile   
 
Help   
About T-Space   

T-Space at The University of Toronto Libraries >
University of Toronto at Scarborough >
Bioline International Legacy Collection >
Bioline International Legacy Collection >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/6149

Title: Helicobacter pylori and histopathological changes of gastric mucosa in Uganda population with varying prevalence of stomach cancer
Authors: Wabinga, Henry
Issue Date: 31-Dec-2005
Publisher: Makerere University Medical School
Citation: African Health Sciences (ISSN: 1680-6905) Vol 5 Num 3
Abstract: Objective: Study the pathological changes in gastric mucosa of Nyarwanda, Nkole (both with high prevalence of stomach cancer) and Ganda (with low prevalence of this cancer) ethnic groups in the presence of Helicobacter pylori (H. pylori) infection. Research question: Do pathological changes accompanying H.pylori infection explain the varying prevalence of stomach cancer in these populations? Design: Retrospective cross sectional study Subjects: A total of 114 patients of the above ethnic groups with upper gastrointestinal symptoms who underwent endoscopic biopsy examination between January 1996 and June 2002 formed the basis of this study. Results: The severity of gastritis correlated with the presence of H. Pylori in Ganda and Nyarwanda but not in Nkole. Intestinal metaplasia (IM) was observed in Nyarwanda and Nkole and in some of these cases there was H. pylori. Gastric atrophy (GA) was also commonly observed in Nkole and Nyarwanda and H. pylori was detected more in the severe form of GA. Lymphoid follicle formation was not associated with H. pylori infection in all study groups. Conclusion: The major histological features relating stomach cancer to H. pylori in this study were presence of the infection in IM and GA that was observed mainly in Nyarwanda and Nkole. The lack of association between presence of lymphoid follicle and H. pylori infection probably explains the rarity of MALT lymphoma in Africa as these tumours are said to arise from H. pylori associated lymphoid follicles.
URI: http://hdl.handle.net/1807/6149
Other Identifiers: http://www.bioline.org.br/abstract?id=hs05040
Rights: Copyright 2005 - Makerere Medical School, Uganda
Appears in Collections:Bioline International Legacy Collection

Files in This Item:

File Description SizeFormat
hs05040.pdf193.63 kBAdobe PDF
View/Open

Items in T-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

uoft