|Title: ||Toxicological assessment of abeere seed (Huntaria umbellata K. Schum)|
|Authors: ||Ibeh, I. N.|
Ataman, J. E.
|Keywords: ||Leucocyte, enzyme, seeds, toxicity, rabbit|
|Issue Date: ||31-Dec-2005|
|Publisher: ||College of Medical Sciences, University of Benin|
|Citation: ||Journal of Medicine and Biomedical Research (ISSN: 1596-6941) Vol 4 Num 1|
|Abstract: ||Thirty age-matched healthy adult male New Zealand white rabbits (2.0
± 0.5kg BW) were randomly divided into six groups (four treatment
and two control groups). The treatment groups were given
intraperitoneal injection of either 0.5ml or 1.0ml liquid extract of
abeere seed or the alcoholic extract (w/v) and examined for 14 days.
The effect of the seed extracts on the haematological parameters,
selected enzymes, liver function and body weights of the affected
rabbits were analysed. There was a shift in the leukocyte population
towards lymphocytes in the rabbits treated with extracts of abeere seed
and a reduction in neutrophylls. An enhancement in the activities of
alkaline phosphatase, aspartate transaminase and alanine transaminase
in rabbits exposed to 0.5ml liquid extract of abeere was observed.
There was no significant difference (p > 0.05) in the histology of
major organs and body weights of test and control rabbits.|
|Other Identifiers: ||http://www.bioline.org.br/abstract?id=jm05006|
|Rights: ||Copyright 2005 - CMS UNIBEN JMBR|
|Appears in Collections:||Bioline International Legacy Collection|