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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/6906

Title: Clinical manifestations and management of cryptococcal infection.
Authors: Subramanian, S.
Mathai, D.
Keywords: AIDS, amphotericin B, Cryptococcus, fluconazole, meningitis
Issue Date: 31-Dec-2005
Publisher: Medknow Publications and Staff Society of Seth GS Medical College and KEM Hospital, Mumbai, India
Citation: Journal of Postgraduate Medicine (ISSN: 0972-2823) Vol 51 Num 5s1
Abstract: Cryptococcus neoformans   is an important fungal pathogen causing invasive infection, especially of the central nervous system in this era of the HIV/AIDS epidemic. The choice of treatment depends on site(s) of infection and the patient′s immune status. Use of appropriate antifungal agents decreases mortality significantly, but requires continued therapy and long-term maintenance to prevent relapses. The use of liposomal amphotericin B (L Amp B) has overcome some of the difficulties usually found in this setting. The major advantage of these liposomal formulations are faster clearance of C. neoformans [cerebrospinal fluid (CSF) negative] and a reduction in amphotericin toxicity. The majority of clinical efficacy data related to L Amp B are derived from compassionate use studies and case series. Use of liposomal amphotericin has also shown to be a cost effective approach.
URI: http://hdl.handle.net/1807/6906
Other Identifiers: http://www.bioline.org.br/abstract?id=jp05128
Rights: Copyright 2005 Journal of Postgraduate Medicine.
Appears in Collections:Bioline International Legacy Collection

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