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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/7356

Title: Full Length Research Article - Effects of chromatographic fractions of Euphorbia hirta on the rat serum biochemistry.
Authors: Adedapo, A. A.
Abatan, M. O.
Idowu, S. O.
Olorunsogo, O. O.
Keywords: E.hirta; chromatographic fractions; serum biochemistry; rats; toxicity
Issue Date: 31-Dec-2005
Publisher: Ibadan Biomedical Communications Group
Citation: African Journal of Biomedical Research (ISSN: 1119-5096) Vol 8 Num 3
Abstract: The effects of the chromatographic fractions of Euphorbia hirta Linn on the serum biochemical parameters in rats were investigated. The ethanolic extract of this plant was subjected to chromatographic separation using the vacuum liquid chromatographic technique, a modified form of classical column chromatography. With the aid of thin layer chromatography, six fractions of this plant were obtained and were administered to rats in graded doses of 400mg/kg, 800mg/kg and 1600mg/kg orally for fourteen days. Some fractions of this plant caused significant increase in the levels of total protein, albumin, globulin, alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), total bilirubin, creatinine, and blood urea nitrogen (BUN). Some fractions also caused significant decrease in the level of conjugated bilirubin. The result from this study thus showed that some chromatographic fractions of Euphorbia hirta have potentially deleterious effects on the serum chemistry of rats; therefore caution should be exercised in the use of Euphorbia hirta as medicinal plant. It also means that the presence of this plant in the pasture could serve as a source of toxicosis to grazing animals.
URI: http://hdl.handle.net/1807/7356
Other Identifiers: http://www.bioline.org.br/abstract?id=md05033
Rights: Copyright 2005 - Ibadan Biomedical Communications Group
Appears in Collections:Bioline International Legacy Collection

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